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Article

The effects of dimethyl sulfoxide and retinoic acid on the cell growth and the phenotype of ovarian cancer cells.

Journal of cell science - 1 Nov 1991

Grunt T W, Somay C, Pavelka M, Ellinger A, Dittrich E, Dittrich C

Abstract excerpt

We have compared the in vitro effects of the differentiation inducers dimethyl sulfoxide (DMSO) and retinoic acid (RA) on a polyclonal human ovarian cancer cell line (HOC-7). Density gradient fractionation of untreated cells reveals that a proportion of rapidly growing, polygonal cells with medium density is capable of spontaneous reversion into a slowly growing low-density phenotype with flattened morphology...

Topics

Cell Differentiation
Cell Division
Cytoskeletal Proteins
Desmoplakins
Dimethyl Sulfoxide
Female
Fibronectins
Humans
Immunohistochemistry
Ovarian Neoplasms
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tretinoin

Tumor Cells, Cultured

Source

Identifiers

PMID: 1808213
DOI: 10.1242/jcs.100.3.657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1808213-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The effects of dimethyl sulfoxide and retinoic acid on the cell growth and the phenotype of ovarian cancer cells.PMID 1808213Read ↗

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