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Article

Phenotypic heterogeneity of human retinal pigment epithelial cells in passaged cell populations.

Journal of bioscience and bioengineering - 1 Aug 2017

Sonoi Rie, Kim Mee-Hae, Yamada Kenta, Kino-Oka Masahiro

Abstract excerpt

Human retinal pigment epithelial (RPE) cells at different population doublings (PDs) were cultured for 28 days to examine their phenotypic heterogeneity in a confluent state. In an early population (PD = 2.8), cells showed a cobblestone-like appearance (type I), which gradually became small and tight, and eventually exhibited dark pigmentation. Some cells showed a dome-like structure (type II), which detached...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28416211
DOI: 10.1016/j.jbiosc.2017.03.008

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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