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Article

Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration.

PloS one - 7 May 2008

Canter Jeffrey A, Olson Lana M, Spencer Kylee, Schnetz-Boutaud Nathalie, Anderson Brent, Hauser Michael A, Schmidt Silke, Postel Eric A, Agarwal Anita, Pericak-Vance Margaret A, Sternberg Paul, Haines Jonathan L

Abstract excerpt

The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for age-related macular degeneration (AMD). A preliminary study of 393 individuals (293 cases and 100 controls) ascertained at Vanderbilt revealed an increased occurrence of 4917G in...

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Identifiers

PMID: 18461138
DOI: 10.1371/journal.pone.0002091
PMCID: PMC2330085

Genes

CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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