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Article

Alterations in the desquamation-related proteolytic cleavage of corneodesmosin and other corneodesmosomal proteins in psoriatic lesional epidermis.

The British journal of dermatology - 1 Jul 2008

Simon M, Tazi-Ahnini R, Jonca N, Caubet C, Cork M J, Serre G

Abstract excerpt

BACKGROUND: Desquamation occurs after proteolysis of corneodesmosomal proteins, including corneodesmosin (CDSN), by proteases of the kallikrein family, particularly KLK7. Impaired desquamation is one of the features of psoriasis, and psoriasis-associated single nucleotide polymorphisms of the CDSN gene may potentially modify the proteolysis of the encoded protein. OBJECTIVES: To test whether the proteolysis of...

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Source

Identifiers

PMID: 18460028
DOI: 10.1111/j.1365-2133.2008.08578.x

Genes

CDSN
KLK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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