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SASPase regulates stratum corneum hydration through profilaggrin‐to‐filaggrin processing

3 May 2011

Abstract excerpt

The stratum corneum (SC), the outermost layer of the epidermis, acts as a barrier against the external environment. It is hydrated by endogenous humectants to avoid desiccation. However, the molecular mechanisms of SC hydration remain unclear. We report that skin-specific retroviral-like aspartic protease (SASPase) deficiency in hairless mice resulted in dry skin and a thicker and less hydrated SC with an...

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PMID: 21542132
DOI: 10.1002/emmm.201100140

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