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Article

Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.

Journal of virology - 1 Apr 1999

Lee M A, Diamond M E, Yates J L

Abstract excerpt

Replication and maintenance of the 170-kb circular chromosome of Epstein-Barr virus (EBV) during latent infection are generally believed to depend upon a single viral gene product, the nuclear protein EBNA-1. EBNA-1 binds to two clusters of sites at oriP, an 1, 800-bp sequence on the EBV genome which can support replication and maintenance of artificial plasmids introduced into cell lines that contain EBNA-1. To...

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Source

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Identifiers

PMID: 10074147
DOI: 10.1128/JVI.73.4.2974-2982.1999
PMCID: PMC104057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.PMID 10074147Read ↗

Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.Semantic proximity Read ↗

Sequence requirements of the Epstein-Barr virus latent origin of DNA replicationSemantic proximity Read ↗

Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replicationSemantic proximity Read ↗

The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfoldSemantic proximity Read ↗

Maintenance of Epstein–Barr virus (EBV) <i>oriP</i> -based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1Semantic proximity Read ↗

Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.Semantic proximity Read ↗

Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of <i>oriP</i> Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1Semantic proximity Read ↗

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance.Semantic proximity Read ↗

The Linking Regions of EBNA1 Are Essential for Its Support of Replication and TranscriptionSemantic proximity Read ↗

Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.Semantic proximity Read ↗

Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids.Semantic proximity Read ↗

The Amino Terminus of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Contains AT Hooks That Facilitate the Replication and Partitioning of Latent EBV Genomes by Tethering Them to Cellular ChromosomesSemantic proximity Read ↗

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