Article
Multiple genotypic aberrances associate to terminal differentiation-deficiency of an oral squamous cell carcinoma in serum-free culture.
Differentiation; research in biological diversity - 1 Oct 2008
Roberg Karin, Ceder Rebecca, Farnebo Lovisa, Norberg-Spaak Lena, Grafström Roland C
Abstract excerpt
Oral squamous cell carcinoma (OSCC) lines proliferative in the serum-free conditions devised for normal oral keratinocytes (NOK) are virtually absent, complicating studies of carcinogenesis. A tongue squamous cell carcinoma generated under conditions for normal cell culture an apparently immortal line (termed LK0412) that has undergone >or=200 population doublings from over a year in culture. LK0412 exhibited...
Topics
- Animals
- Apoptosis
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Line, Transformed
- Cell Line, Tumor
- Cell Proliferation
- Culture Media, Serum-Free
- Female
- Genotype
- Humans
- Keratinocytes
- Mice
- Mice, Inbred BALB C