Article
SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line.
The FEBS journal - 1 Sept 2017
Sobral Lays M, Coletta Ricardo D, Alberici Luciane C, Curti Carlos, Leopoldino Andréia M
Abstract excerpt
The multifunctional SET/I2PP2A protein is known to be overexpressed in head and neck squamous cell carcinoma. However, SET has been reported to have apparently conflicting roles in promoting cancer cell survival under oxidative stress conditions and preventing invasion and metastasis, complicating efforts to understand the contribution of SET to carcinogenesis. In the present study, we overexpressed SETin a...
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