Article
Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in Chinese cancer patients.
Journal of clinical pharmacy and therapeutics - 1 Jun 2008
He Y-F, Wei W, Zhang X, Li Y-H, Li S, Wang F-H, Lin X-B, Li Z-M, Zhang D-S, Huang H-Q, Hu B, Jiang W-Q
Abstract excerpt
BACKGROUND AND OBJECTIVE: 5-fluorouracil (5-FU) is still a widely used anticancer drug. More than 85% of the 5-FU administered is catabolized by dihydropyrimidine dehydrogenase (DPD) in the liver. However, mutations in the DPD gene have been found to be associated with low DPD activity causing severe complications. The purpose of this study was to determine the mutation frequency of four exons in Chinese cancer...
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