Article
High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism.
International journal of oncology - 1 Feb 2003
Gross Eva, Seck Katharina, Neubauer Steffi, Mayr Jutta, Hellebrand Heide, Ratanaphan Adisorn, Lutz Verena, Stockinger Hubertus, Kiechle Marion
Abstract excerpt
Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the degradation of pyrimidines and pyrimidine base analogs including the anticancer drugs 5-fluorouracil (5-FU) and Xeloda. A decreased DPD enzyme activity has been described in cancer patients experiencing severe and life-threatening toxicity after 5-FU treatment and distinct sequence variants in the DPD gene (DPYD) have been...
Topics
- Adult
- Alleles
- Amino Acid Substitution
- Antineoplastic Agents
- Biotransformation
- Capecitabine
- Chromatography, High Pressure Liquid
- DNA Mutational Analysis
- Deoxycytidine
- Dihydrouracil Dehydrogenase (NADP)
- Exons
- Female
- Fluorouracil