Mutation topography and risk stratification for de novo acute myeloid leukaemia with normal cytogenetics and no nucleophosmin 1 (NPM1) mutation or Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD).

doi:10.1111/bjh.16526

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mutation topography and risk stratification for de novo acute myeloid leukaemia with normal cytogenetics and no nucleophosmin 1 (NPM1) mutation or Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD).

British journal of haematology - 1 Jul 2020

Zhou Ya-Lan, Wu Li-Xin, Peter Gale Robert, Wang Zi-Long, Li Jin-Lan, Jiang Hao, Jiang Qian, Jiang Bin, Cao Shan-Bo, Lou Feng, Sun Ying, Wang Cheng-Cheng, Liu Yan-Rong, Wang Yu, Chang Ying-Jun, Xu Lan-Ping, Zhang Xiao-Hui, Liu Kai-Yan, Ruan Guo-Rui, Huang Xiao-Jun

Abstract excerpt

About 25% of patients with newly diagnosed acute myeloid leukaemia (AML) have normal cytogenetics and no nucleophosmin 1 (NPM1) mutation or Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD). The prognosis and best therapy for these patients is controversial. We evaluated 158 newly diagnosed adults with this genotype who achieved histological complete remission within two cycles of induction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged

Share to Cytogenetic Analysis

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Nucleophosmin

Share to Tandem Repeat Sequences

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 32103499
DOI: 10.1111/bjh.16526

Genes

FLT3
NPM1
CSF3R
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation topography and risk stratification for de novo acute myeloid leukaemia with normal cytogenetics and no nucleophosmin 1 (NPM1) mutation or Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD).PMID 32103499Read ↗

Acute Myeloid Leukaemia with Normal Cytogenetics and NPM1-Mutation: Impact of Mutation Topography on OutcomesSemantic proximity Read ↗

Cytogenetically Normal Acute Myeloid Leukaemia at a Single Centre in South Africa.Semantic proximity Read ↗

Identification of relapse-associated gene mutations by next-generation sequencing in low-risk acute myeloid leukaemia patients.Semantic proximity Read ↗

Complex karyotype but not other cytogenetic abnormalities is associated with worse posttransplant survival of patients with nucleophosmin 1-mutated acute myeloid leukemia: A study from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party.Semantic proximity Read ↗

Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.Semantic proximity Read ↗

Genetic biomarkers identify a subgroup of high-risk patients within low-risk NPM1-mutated acute myeloid leukemia.Semantic proximity Read ↗

Mutational landscape of AML with normal cytogenetics: biological and clinical implications.Semantic proximity Read ↗

Bioinformatics Analysis to Determine Prognostic Mutations of 72 de novo Acute Myeloid Leukemia Cases from the Cancer Genome Atlas (TCGA) with 23 Most Common Mutations and no Abnormal Cytogenetics.Semantic proximity Read ↗

Prognostic significance of FLT3 internal tandem duplication, nucleophosmin 1, and CEBPA gene mutations for acute myeloid leukemia patients with normal karyotype and younger than 60 years: a systematic review and meta-analysis.Semantic proximity Read ↗

Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International CohortsSemantic proximity Read ↗

Measurable residual disease, FLT3-ITD mutation, and disease status have independent prognostic influence on outcome of allogeneic stem cell transplantation in NPM1-mutated acute myeloid leukemia.Semantic proximity Read ↗

Impact of genomics in the clinical management of patients with cytogenetically normal acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.