Article
A novel predictive technique for the MHC class II peptide-binding interaction.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Davies Matthew N, Sansom Clare E, Beazley Claude, Moss David S
Abstract excerpt
Antigenic peptide is presented to a T-cell receptor through the formation of a stable complex with a Major Histocompatibility Complex (MHC) molecule. Various predictive algorithms have been developed to estimate a peptide's capacity to form a stable complex with a given MHC Class II allele, a technique integral to the strategy of vaccine design. These have previously incorporated such computational techniques as...
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