Article
Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death.
PloS one - 1 Jan 2012
Chi Jingwei, Li Li, Liu Mujun, Tan Jieqiong, Tang Chengyuan, Pan Qian, Wang Danling, Zhang Zhuohua
Abstract excerpt
Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31 pathogenic mutants remains largely elusive. We report here that expression of EKV pathogenic mutant Cx31R42P induces cell death with necrotic characteristics. Inhibition of hemichannel activity by a connexin hemichannel inhibitor or high extracellular calcium...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.