Article
Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis.
Clinical immunology (Orlando, Fla.) - 1 Jul 2008
Slot Marjan C, Sokolowska Milena G, Savelkouls Kim G, Janssen Rob G J H, Damoiseaux Jan G M C, Tervaert Jan Willem Cohen
Abstract excerpt
T cell activation is regulated by inhibitory molecules such as PD-1 and CTLA-4, whose expression may be affected by gene polymorphisms. Increased T cell activation is present in patients with ANCA-associated vasculitis (AAV). We investigated two single-nucleotide polymorphisms (SNPs) in PDCD1 and five polymorphisms in CTLA4 in 102 patients with AAV and 188 healthy controls (HC). The distributions of the PD-1.3...
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