Article
Gene variants and treatment outcomes in antineutrophil cytoplasmic antibody-associated vasculitis.
The pharmacogenomics journal - 1 Dec 2020
Hessels Arno C, Sanders Jan Stephan F, Rutgers Abraham, Stegeman Coen A
Abstract excerpt
The introduction of immunosuppressive therapy for ANCA-associated vasculitis (AAV) has greatly improved outcomes, though patients now accumulate damage from vasculitis activity and adverse effects of treatment. Prediction of treatment outcomes using gene variants might help reduce this damage by allowing for personalized treatment. Several studies have studied genetic polymorphisms in relation to treatment...
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