Article
Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jul 2012
Satirapoj Bancha, Wang Ying, Chamberlin Mina P, Dai Tiane, LaPage Janine, Phillips Lynetta, Nast Cynthia C, Adler Sharon G
Abstract excerpt
BACKGROUND: Periostin acts as an adhesion molecule during bone formation. Knowledge of its expression in kidney injury is scant. METHODS: We investigated periostin function and expression in vivo in Sprague-Dawley rats after 5/6 nephrectomy (Nx), in DBA2J mice with streptozotocin-induced diabetic nephropathy (SZ-DN) and unilateral ureteral obstruction (UUO) and in vitro in mouse distal collecting tubular cells...
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