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Article

Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition.

Antimicrobial agents and chemotherapy - 1 Jul 2008

Fransen Signe, Bridger Gary, Whitcomb Jeannette M, Toma Jonathan, Stawiski Eric, Parkin Neil, Petropoulos Christos J, Huang Wei

Abstract excerpt

In a phase I/II evaluation of the CXCR4 antagonist AMD3100, human immunodeficiency virus RNA levels were significantly reduced in a single study subject who harbored CXCR4 (X4)-tropic virus, but not in subjects who harbored either dual/mixed (DM)-tropic or CCR5 (R5)-tropic virus (C. W. Hendrix et al., J. Acquir. Immune Defic. Syndr. 37:1253-1262, 2004). In this study, we analyzed the envelope clones of DM-tropic...

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Identifiers

PMID: 18443125
DOI: 10.1128/AAC.01226-07
PMCID: PMC2443920

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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