Article
5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes.
Science (New York, N.Y.) - 14 Sept 1990
Rideout W M, Coetzee G A, Olumi A F, Jones P A
Abstract excerpt
Direct genomic sequencing revealed that cytosine residues known to have undergone a germ-line mutation in the low density lipoprotein receptor gene or somatic mutations in the p53 tumor suppressor gene were methylated in all normal human tissues analyzed. Thus, these mutations should be scored as transitions from 5-methylcytosine to thymine rather than from cytosine to thymine. Methylated cytosines occur...
Topics
- 5-Methylcytosine
- Base Sequence
- Cytosine
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Dinucleoside Phosphates
- Guanosine
- Humans
- Leukocytes
- Male
- Methylation