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Article

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.

Journal of molecular biology - 30 May 2008

Chen Weijun, Srinath Hema, Lam Suvana S, Schiffer Celia A, Royer William E, Lin Kai

Abstract excerpt

IRF-3, a member of the interferon regulatory factor (IRF) family of transcription factors, functions in innate immune defense against viral infection. Upon infection, host cell IRF-3 is activated by phosphorylation at its seven C-terminal Ser/Thr residues: (385)SSLENTVDLHISNSHPLSLTS(405). This phosphoactivation triggers IRF-3 to react with the coactivators, CREB-binding protein (CBP)/p300, to form a complex that...

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Identifiers

PMID: 18440553
DOI: 10.1016/j.jmb.2008.03.050
PMCID: PMC2410038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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