Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

The Journal of biological chemistry - 14 Mar 2003

Servant Marc J, Grandvaux Nathalie, tenOever Benjamin R, Duguay Delphine, Lin Rongtuan, Hiscott John

Abstract excerpt

The ubiquitously expressed latent interferon regulatory factor (IRF) 3 transcription factor is activated in response to virus infection by phosphorylation events that target a cluster of Ser/Thr residues, (382)GGASSLENTVDLHISNSHPLSLTSDQY(408) at the C-terminal end of the protein. To delineate the minimal phosphoacceptor sites required for IRF-3 activation, several point mutations were generated and tested for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Proteins
Share to Chemokine CCL5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-beta

Share to Interferon Regulatory Factor-3

Share to RNA, Double-Stranded

Share to Sendai virus

Share to Toll-Like Receptors

Share to U937 Cells

Source

Identifiers

PMID: 12524442
DOI: 10.1074/jbc.M209851200

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.PMID 12524442Read ↗

Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation.Semantic proximity Read ↗

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.Semantic proximity Read ↗

Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.Semantic proximity Read ↗

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.Semantic proximity Read ↗

Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.Semantic proximity Read ↗

Functional analysis of nsP3 phosphoprotein mutants of Sindbis virus.Semantic proximity Read ↗

Functional significance of alternate phosphorylation in Sendai virus P protein.Semantic proximity Read ↗

Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.Semantic proximity Read ↗

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.Semantic proximity Read ↗

Serine 3 is critical for phosphorylation at the N-terminal end of the nucleoprotein of influenza virus A/Victoria/3/75.Semantic proximity Read ↗

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3Semantic proximity Read ↗

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.