Article
A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.
The Journal of biological chemistry - 2 Jul 1999
Febbraio M, Abumrad N A, Hajjar D P, Sharma K, Cheng W, Pearce S F, Silverstein R L
Abstract excerpt
A null mutation in the scavenger receptor gene CD36 was created in mice by targeted homologous recombination. These mice produced no detectable CD36 protein, were viable, and bred normally. A significant decrease in binding and uptake of oxidized low density lipoprotein was observed in peritoneal macrophages of null mice as compared with those from control mice. CD36 null animals had a significant increase in...
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