Article
Expression of nuclear XIAP associates with cell growth and drug resistance and confers poor prognosis in breast cancer.
Biochimica et biophysica acta. Molecular cell research - 1 Oct 2020
Delbue Deborah, Mendonça Bruna S, Robaina Marcela C, Lemos Lauana G T, Lucena Pedro I, Viola João P B, Magalhães Lídia M, Crocamo Susanne, Oliveira Caio A B, Teixeira Felipe R, Maia Raquel C, Nestal de Moraes Gabriela
Abstract excerpt
Evasion from apoptosis is one of the hallmarks of cancer. X-linked inhibitor of apoptosis protein (XIAP) is known to modulate apoptosis by inhibiting caspases and ubiquitinating target proteins. XIAP is mainly found at the cytoplasm, but recent data link nuclear XIAP to poor prognosis in breast cancer. Here, we generated a mutant form of XIAP with a nuclear localization signal (XIAPNLS-C-term) and investigated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.