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Article

Investigation of association between the TRAF family genes and RA susceptibility.

Annals of the rheumatic diseases - 1 Oct 2007

Potter Catherine, Eyre Stephen, Cope Andrew, Worthington Jane, Barton Anne

Abstract excerpt

OBJECTIVE: The tumour necrosis factor (TNF) receptor-associated factor (TRAF) family is important in activating multiple inflammatory and immune related processes induced by cytokines such as TNFalpha and interleukin-1. These genes therefore represent strong candidate susceptibility factors for rheumatoid arthritis (RA). A study was undertaken to investigate the association between single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17277003
DOI: 10.1136/ard.2006.065706
PMCID: PMC1994286

Genes

TRAF5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Investigation of association between the TRAF family genes and RA susceptibility.PMID 17277003Read ↗

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.Semantic proximity Read ↗

Association between polymorphism in TRAF1/C5 gene and risk of rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

Association of a TRAF1 and a STAT4 gene polymorphism with increased risk for rheumatoid arthritis in a genetically homogeneous population.Semantic proximity Read ↗

Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.Semantic proximity Read ↗

Associations between TRAF1-C5 gene polymorphisms and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population.Semantic proximity Read ↗

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.Semantic proximity Read ↗

Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.Semantic proximity Read ↗

TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians.Semantic proximity Read ↗

Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study.Semantic proximity Read ↗

Association of the TRAF1/C5 locus with increased mortality, particularly from malignancy or sepsis, in patients with rheumatoid arthritis.Semantic proximity Read ↗

Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.Semantic proximity Read ↗

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