Molecular mechanism for establishment of signal-dependent regulation in the PhoP/PhoQ system.

Abstract excerpt

In this report, we demonstrate that H-NS is essential for establishing the Mg(2+)-responsive transcriptional regulation of the PhoP regulon in Salmonella. Deletion of this regulatory gene abolished the transcriptional repression of PhoP-activated genes when bacteria were grown in high environmental Mg(2+), thus stimulating expression of phoP and other PhoP regulon genes. In the absence of H-NS, transcriptional...

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