Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility.

doi:10.1677/ERC-07-0257

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Article

Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility.

Endocrine-related cancer - 1 Jun 2008

Ferlin Alberto, Pengo Manuel, Selice Riccardo, Salmaso Luigi, Garolla Andrea, Foresta Carlo

Abstract excerpt

The development of testicular germ cell tumour (TGCT) is believed to be under endocrine control but definitive proofs are lacking. Follicle stimulating hormone (FSH) levels are increased in numerous conditions associated with increased risk of TGCT and single nucleotide polymorphisms (SNPs) in the FSH receptor (FSHR) gene influence the sensitivity of the receptor to FSH. However, a possible effect of FSH on...

Topics

Adult
Genetic Predisposition to Disease
Haplotypes
Humans
Male
Neoplasms, Germ Cell and Embryonal
Polymorphism, Single Nucleotide
Receptors, FSH
Risk Factors
Seminoma
Testicular Neoplasms

Source

Open in PubMed

Identifiers

PMID: 18430895
DOI: 10.1677/ERC-07-0257

Genes

FSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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