Article
Association between follicle-stimulating hormone receptor polymorphisms and reproductive parameters in young men from the general population.
Pharmacogenetics and genomics - 1 Sept 2012
Lindgren Ida, Giwercman Aleksander, Axelsson Jonatan, Lundberg Giwercman Yvonne
Abstract excerpt
OBJECTIVE: Follicle-stimulating hormone (FSH) regulates gametogenesis through binding to its receptor (FSHR). In women, the Thr307Ala and Asn680Ser polymorphisms in the FSHR gene affect reproductive function, but it is not clear whether they have any impact on spermatogenesis and have mainly been investigated in infertile men of varying ages. The aim of the present study was therefore to examine whether these...
Topics
- Adolescent
- Estradiol
- Female
- Follicle Stimulating Hormone
- Gene Frequency
- Genetic Association Studies
- Genetics, Population
- Genotype
- Humans
- Male
- Polymorphism, Single Nucleotide
- Receptors, FSH
- Reproduction
- Sex Hormone-Binding Globulin
- Spermatozoa
- Testis
- Young Adult