Article
Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility.
Carcinogenesis - 1 Jul 2006
Yang C Q, Chan K Y K, Ngan H Y S, Khoo U S, Chiu P M, Chan Q K Y, Xue W C, Cheung A N Y
Abstract excerpt
Epidemiological studies suggested that ovulation was associated with ovarian carcinogenesis. Follicle-stimulating hormone (FSH) played an important role in follicular development and was recently found to affect growth of ovarian epithelial cells. Single nucleotide polymorphisms (SNPs) Thr307Ala and Asn680Ser were two non-synonymous variations in the coding region of the FSH receptor (FSHR) gene. This hitherto...
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