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Article

EBV transformation overrides gene expression patterns of B cell differentiation stages.

Molecular immunology - 1 Jun 2008

Siemer Dörte, Kurth Julia, Lang Stephan, Lehnerdt Götz, Stanelle Jens, Küppers Ralf

Abstract excerpt

EBV-associated Hodgkin lymphoma (HL) and some post-transplant lymphoproliferative disease (PTLD) cases originate from pro-apoptotic germinal center (GC) B cells that have acquired destructive somatic Ig V gene mutations and were presumably rescued from apoptosis by EBV. To find out whether B cell receptor-crippled GC B cells acquire features of HL and/or PTLD cells upon EBV-infection and to reveal the impact of...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Herpesvirus 4, Human

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Share to Somatic Hypermutation, Immunoglobulin

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Source

Identifiers

PMID: 18430472
DOI: 10.1016/j.molimm.2008.03.002

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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