Virulent <i>Shigella flexneri</i> subverts the host innate immune response through manipulation of antimicrobial peptide gene expression

Abstract excerpt

Antimicrobial factors are efficient defense components of the innate immunity, playing a crucial role in the intestinal homeostasis and protection against pathogens. In this study, we report that upon infection of polarized human intestinal cells in vitro, virulent Shigella flexneri suppress transcription of several genes encoding antimicrobial cationic peptides, particularly the human beta-defensin hBD-3, which...

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