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Secretory IgA-Mediated Neutralization of <i>Shigella flexneri</i> Prevents Intestinal Tissue Destruction by Down-Regulating Inflammatory Circuits

14 Oct 2009

Abstract excerpt

Shigella, a Gram-negative invasive enteropathogenic bacterium responsible for bacillary dysentery, causes the rupture, invasion, and inflammatory destruction of the human colonic mucosa. We explored the mechanisms of protection mediated by Shigella LPS-specific secretory IgA (SIgA), the major mucosal Ab induced upon natural infection. Bacteria, SIgA, or SIgA-S. flexneri immune complexes were administered into...

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PMID: 19828639
DOI: 10.4049/jimmunol.0901838

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