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Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.

Diabetes - 1 Nov 2006

Lyon Helen N, Florez Jose C, Bersaglieri Todd, Saxena Richa, Winckler Wendy, Almgren Peter, Lindblad Ulf, Tuomi Tiinamaija, Gaudet Daniel, Zhu Xiaofeng, Cooper Richard, Ardlie Kristin G, Daly Mark J, Altshuler David, Groop Leif, Hirschhorn Joel N

Abstract excerpt

The common missense single nucleotide polymorphism (SNP) K121Q in the ectoenzyme nucleotide pyrophosphate phosphodiesterase (ENPP1) gene has recently been associated with type 2 diabetes in Italian, U.S., and South-Asian populations. A three-SNP haplotype, including K121Q, has also been associated with obesity and type 2 diabetes in French and Austrian populations. We set out to confirm these findings in several...

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Identifiers

PMID: 17065359
DOI: 10.2337/db06-0407

Genes

ENPP1

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Related research

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Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.PMID 17065359Read ↗

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population.Semantic proximity Read ↗

Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.Semantic proximity Read ↗

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