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Article

The ENPP1 K121Q polymorphism is associated with type 2 diabetes and related metabolic phenotypes in a Taiwanese population.

Molecular and cellular endocrinology - 15 Sept 2016

Hsiao Tun-Jen, Lin Eugene

Abstract excerpt

Increased risk of developing type 2 diabetes (T2D) has been associated with a single nucleotide polymorphism (SNP), rs1044498 (K121Q), in the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene, but this association is unclear among Asians. In this replication study, we reassessed whether the ENPP1 rs1044498 SNP is associated with T2D, obesity, and T2D/obesity-related metabolic traits in a Taiwanese...

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Source

Identifiers

PMID: 27238374
DOI: 10.1016/j.mce.2016.05.020

Genes

ENPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The ENPP1 K121Q polymorphism is associated with type 2 diabetes and related metabolic phenotypes in a Taiwanese population.PMID 27238374Read ↗

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.Semantic proximity Read ↗

Association of the ENPP1 K121Q polymorphism with susceptibility to type 2 diabetes in different populations: evidence based on 40 studies.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and type 2 diabetes mellitus in the Chinese population: a meta-analysis including 11,855 subjects.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

Gender differences in the association of ENPP1 polymorphisms with type 2 diabetes in a Chinese population.Semantic proximity Read ↗

Ectonucleotide pyrophosphatase/phosphodiesterase 1 K173Q polymorphism is associated with diabetic nephropathy in the Taiwanese population.Semantic proximity Read ↗

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