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Article

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.

The Journal of biological chemistry - 4 Jun 2010

Page Richard M, Gutsmiedl Amelie, Fukumori Akio, Winkler Edith, Haass Christian, Steiner Harald

Abstract excerpt

Pathogenic generation of the 42-amino acid variant of the amyloid beta-peptide (Abeta) by beta- and gamma-secretase cleavage of the beta-amyloid precursor protein (APP) is believed to be causative for Alzheimer disease (AD). Lowering of Abeta(42) production by gamma-secretase modulators (GSMs) is a hopeful approach toward AD treatment. The mechanism of GSM action is not fully understood. Moreover, whether GSMs...

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Identifiers

PMID: 20348104
DOI: 10.1074/jbc.M110.103283
PMCID: PMC2878544

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.PMID 20348104Read ↗

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