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Article

Effects of single-point amino acid substitutions on the structure and function neuraminidase proteins in influenza A virus.

Microbiology and immunology - 1 Apr 2008

Yano Takuya, Nobusawa Eri, Nagy Alexander, Nakajima Setsuko, Nakajima Katsuhisa

Abstract excerpt

In order to clarify the effect of amino acid substitutions on the structure and function of the neuraminidase (NA) protein of influenza A virus, we introduced single-point amino acid substitutions into the NA protein of the A/Tokyo/3/67 (H2N2) strain using PCR-based random mutation. The rate of tolerant random one amino acid substitutions in the NA protein was 47%. Rates of tolerant substitutions for the stalk...

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Source

Identifiers

PMID: 18426396
DOI: 10.1111/j.1348-0421.2008.00034.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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