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Article

Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene.

Biological psychiatry - 15 Oct 2007

Huo Liang, Straub Richard E, Roca Catherine, Schmidt Peter J, Shi Kai, Vakkalanka Radhakrishna, Weinberger Daniel R, Rubinow David R

Abstract excerpt

BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women. METHODS: We performed haplotype analyses of estrogen receptors alpha and beta (ESR1 and ESR2) in 91 women with prospectively confirmed PMDD and 56 control subjects to investigate possible sources of the genetic susceptibility to affective dysregulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17599809
DOI: 10.1016/j.biopsych.2006.12.019
PMCID: PMC2762203

Genes

ESR1
COMT
ESR2

Provenance

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Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene.PMID 17599809Read ↗

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