Article
The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies.
Journal of reproductive immunology - 1 Jul 2008
Iversen Ann-Charlotte, Nguyen Olav Toai Duc, Tømmerdal Linda Føll, Eide Irina Poliakova, Landsem Veslemøy Malm, Acar Nuray, Myhre Ronny, Klungland Helge, Austgulen Rigmor
Abstract excerpt
Trophoblast expression of the non-classical MHC, HLA-G, is considered essential for feto-maternal immune tolerance and successful placentation in pregnancy. The HLA-G 14bp polymorphism in the 3'-untranslated region (UTR) of the HLA-G gene has been reported to be associated with development of pre-eclampsia (PE). In this study, maternal (peripheral blood, n=54) and fetal (cord blood, n=57) HLA-G 14bp genotypes...
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