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Article

Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.

PloS one - 1 Jan 2015

Yıldırım Cansu, Vogel Daphne Y S, Hollander Maurits R, Baggen Josefien M, Fontijn Ruud D, Nieuwenhuis Sylvia, Haverkamp Anouk, de Vries Margreet R, Quax Paul H A, Garcia-Vallejo Juan J, van der Laan Anja M, Dijkstra Christine D, van der Pouw Kraan Tineke C T M, van Royen Niels, Horrevoets Anton J G

Abstract excerpt

Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of galectin-2 on arteriogenesis was confirmed in vivo, but the mechanism is largely unknown. In this study we aimed to explore the effects of galectin-2 on...

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Identifiers

PMID: 25884209
DOI: 10.1371/journal.pone.0124347
PMCID: PMC4401781

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TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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