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Article

Distinct immune-metabolic phenotypes underlie poor coronary collateral circulation.

Cardiovascular diabetology - 18 Nov 2025

Guo Zi-Tong, Lai Hong-Mei, Hu Run-Xuan, Qiu Ya-Jing, Tao Jing, Yu Xiao-Lin, Yang Yi-Ning

Abstract excerpt

BACKGROUND: Coronary collateral circulation (CCC) significantly impacts myocardial perfusion and clinical outcomes in coronary artery disease patients, yet the underlying molecular heterogeneity remains inadequately characterized. OBJECTIVE: To identify distinct molecular phenotypes in patients with poor CCC, validate these phenotypes using clinical parameters, and evaluate their prognostic implications. METHODS:...

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Topics

Humans
Collateral Circulation
Coronary Artery Disease
Female
Male
Middle Aged
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Coronary Circulation

Proteomics

Aged

Prognosis

Risk Assessment

Reproducibility of Results

Risk Factors

Biomarkers

Source

Open in PubMed Open full text

Identifiers

PMID: 41254693
DOI: 10.1186/s12933-025-02988-y
PMCID: PMC12625015

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