Article
Alopecia universalis associated with a mutation in the human hairless gene.
Science (New York, N.Y.) - 30 Jan 1998
Ahmad W, Faiyaz ul Haque M, Brancolini V, Tsou H C, ul Haque S, Lam H, Aita V M, Owen J, deBlaquiere M, Frank J, Cserhalmi-Friedman P B, Leask A, McGrath J A, Peacocke M, Ahmad M, Ott J, Christiano A M
Abstract excerpt
There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established...
Topics
- Alopecia
- Amino Acid Sequence
- Animals
- Brain
- Chromosome Mapping
- Chromosomes, Human, Pair 8
- DNA-Binding Proteins
- Female
- Forkhead Transcription Factors
- Gene Expression
- Genes, Recessive
- Homozygote
- Humans
- Male