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Article

Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer

1 May 2010

Abstract excerpt

BACKGROUND: LIM and SH3 protein 1 (LASP-1) is a nucleo-cytoplasmatic signalling protein involved in cell proliferation and migration and is upregulated in breast cancer in vitro studies have shown that LASP-1 might be regulated by prostate-derived ETS factor (PDEF), p53 and/or LASP1 gene amplification. This current study analysed the prognostic significance of LASP-1 on overall survival (OS) in 177 breast cancer...

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PMID: 20461080
DOI: 10.1038/sj.bjc.6605685

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