Article
Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2017
Yang Hee Jung, Zhang Jin, Yan Wensheng, Cho Seong-Jun, Lucchesi Christopher, Chen Mingyi, Huang Eric C, Scoumanne Ariane, Zhang Weici, Chen Xinbin
Abstract excerpt
WT p53 is critical for tumor suppression, whereas mutant p53 promotes tumor progression. Nerve injury-induced protein 1 (Ninj1) is a target of p53 and forms a feedback loop with p53 by repressing p53 mRNA translation. Here, we show that loss of Ninj1 increased mutant p53 expression and, subsequently, enhanced cell growth and migration in cells carrying a mutant p53. In contrast, loss of Ninj1 inhibited cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.