Article
Plasma drug concentrations and virologic evaluations after stopping treatment with nonnucleoside reverse-transcriptase inhibitors in HIV type 1-infected children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 May 2008
Cressey Tim R, Green Hannah, Khoo Saye, Treluyer Jean-Marc, Compagnucci Alexandra, Saidi Yacine, Lallemant Marc, Gibb Diana M, Burger David M
Abstract excerpt
BACKGROUND: The optimum strategy for stopping treatment with drugs that have different half-lives in a combination regimen to minimize the risk of selecting drug-resistant viruses remains unknown. We evaluated drug concentrations in plasma, human immunodeficiency virus (HIV) load, and development of drug resistance after a planned treatment interruption of a nonnucleoside reverse-transcriptase inhibitor...
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