Article
Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis.
Contact dermatitis - 1 May 2008
de Jongh Cindy M, John Swen M, Bruynzeel Derk P, Calkoen Florentine, van Dijk Frank J H, Khrenova Liubov, Rustemeyer Thomas, Verberk Maarten M, Kezic Sanja
Abstract excerpt
BACKGROUND: Cytokines play an important role in skin inflammation. OBJECTIVES: We determined whether polymorphisms in cytokine genes contribute to the occurrence of occupational chronic irritant contact dermatitis (CICD). METHODS: In a case-control study, 9 polymorphisms in the genes coding for interleukin (IL)-1 alpha, IL-1 beta, IL-8, IL-10, and tumour necrosis factor (TNF)-alpha were determined in 197 patients...
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