Article
Cytokine gene polymorphisms in allergic contact dermatitis.
Contact dermatitis - 1 Feb 2003
Westphal Götz A, Schnuch Axel, Moessner Rotraut, König Inke R, Kränke Birger, Hallier Ernst, Ziegler Andreas, Reich Kristian
Abstract excerpt
Susceptibility to contact allergy may be influenced by genetically determined alterations in the production of pro- and anti-inflammatory cytokines. This report focuses on functional polymorphisms in the genes encoding for several cytokines involved in the pathogenesis of contact allergic responses, including tumour necrosis factor (TNF)-alpha (G-238 A, G-308 A), interleukin (IL)-1beta (C-511G, T+ 3953C), its...
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