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Article

[c-Kit and PDGFRA mutations and clinico-morphological features of gastrointestinal stromal tumors].

Voprosy onkologii - 1 Jan 2007

Beliakov I S, Anurova O A, Snigur P V, Tsyganova I V, Sel'chuk V Iu, Mazurenko N N

Abstract excerpt

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the digestive tract. Inherent overexpression of receptor tyrosine kinase KIT (CD117) and mutations in c-Kit or PDGFRA genes are highly significant prognosticators. A first Russian investigation of c-Kit and PDGFRA mutations in GIST was carried out in 60 patients. c-Kit mutations were identified in 83.3% (50/60), the most frequent...

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Source

Identifiers

PMID: 18416137

Genes

PDGFRA
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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