Article
Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation.
Cell cycle (Georgetown, Tex.) - 1 Apr 2008
Rowbotham Nicola J, Furmanski Anna L, Hager-Theodorides Ariadne L, Ross Susan E, Drakopoulou Ekati, Koufaris Costas, Outram Susan V, Crompton Tessa
Abstract excerpt
Hedgehog proteins signal for differentiation, survival and proliferation of the earliest thymocyte progenitors, but their functions at later stages of thymocyte development and in peripheral T-cell function are controversial. Here we show that repression of Hedgehog (Hh) pathway activation in T-lineage cells, by expression of a transgenic repressor form of Gli2 (Gli2DeltaC2), increased T-cell differentiation and...
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