Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines.

Abstract excerpt

Although mutations in intermediate filament proteins cause many human disorders, the detailed pathogenic mechanisms and the way these mutations affect cell metabolism are unclear. In this study, selected keratin mutations were analysed for their effect on the epidermal stress response. Expression profiles of two keratin-mutant cell lines from epidermolysis bullosa simplex patients (one severe and one mild) were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Dual-Specificity Phosphatases
• Share to Epidermolysis Bullosa Simplex