Article
Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients.
Clinical endocrinology - 1 Nov 2008
van der Deure Wendy M, Appelhof Bente C, Peeters Robin P, Wiersinga Wilmar M, Wekking Ellie M, Huyser Jochanan, Schene Aart H, Tijssen Jan G P, Hoogendijk Witte J G, Visser Theo J, Fliers Eric
Abstract excerpt
INTRODUCTION: Some hypothyroid patients continue to have significant impairments in psychological well-being, despite adequate treatment with levothyroxine (LT4). T4 transport across the blood-brain barrier is one of the crucial processes for thyroid hormone action in the brain. OATP1C1, a thyroid hormone transporter expressed at the blood-brain barrier, is considered to play a key role in delivering serum T4 to...
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