Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with <i>EGFR</i>amplification

10 Apr 2008

Abstract excerpt

The ERK1/2 activated protein kinase (MAPK) pathway is a critical signaling system that mediates ligand-stimulated signals for the induction of cell proliferation, differentiation and survival, involved in malignant transformation. The purpose of this study was to determine the activation of ERK1/2 in this tumor, and to determine the relationship of ERK1/2 activation with the amplification/overexpression of EGFR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Glioma Diagnosis and Treatment
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18410277
DOI: 10.1111/j.1440-1789.2008.00911.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with <i>EGFR</i>amplificationPMID 18410277Read ↗

Updated Insights on EGFR Signaling Pathways in GliomaSemantic proximity Read ↗

Primary glioblastomas with and without EGFR amplification: Relationship to genetic alterations and clinicopathological featuresSemantic proximity Read ↗

Genetic Alterations of Epidermal Growth Factor Receptor in Glioblastoma: The Usefulness of Immunohistochemistry.Semantic proximity Read ↗

New pattern of EGFR amplification in glioblastoma and the relationship of gene copy number with gene expression profile.Semantic proximity Read ↗

Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic <i>in situ</i> hybridization: association with clinicopathological features and patient survivalSemantic proximity Read ↗

Epidermal growth factor receptor targeting and challenges in glioblastomaSemantic proximity Read ↗

p53 mutation and epidermal growth factor receptor overexpression in glioblastoma.Semantic proximity Read ↗

Amplification of the epidermal growth factor receptor gene in glioblastoma: an analysis of the relationship between genotype and phenotype by CISH method.Semantic proximity Read ↗

Epidermal Growth Factor Receptor Gene Amplification and Protein Expression in Glioblastoma MultiformeSemantic proximity Read ↗

Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells.Semantic proximity Read ↗

Amplification of Epidermal Growth Factor Receptor Gene in Gliomas: Histopathology and PrognosisSemantic proximity Read ↗

Epidermal growth factor receptor in glioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.