Article
PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
Oncogene - 7 Aug 2008
Yu J S, Koujak S, Nagase S, Li C-M, Su T, Wang X, Keniry M, Memeo L, Rojtman A, Mansukhani M, Hibshoosh H, Tycko B, Parsons R
Abstract excerpt
Carcinoma is an altered state of tissue differentiation in which epithelial cells no longer respond to cues that keep them in their proper position. A break down in these cues has disastrous consequences not only in cancer but also in embryonic development when cells of various lineages must organize into discrete entities to form a body plan. Paraxial protocadherin (PAPC) is an adhesion protein with six cadherin...
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